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three integrin activation. Importantly, we show that early signaling functions associated with Src activation dictate the proaggregatory phenotype from the KI mice.
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These molecular alterations can have reached “ceiling ranges” in KI platelets, as activation of PAR4 signaling isn't going to even more greatly enhance Src phosphorylation.
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Just after administration of agonist in vivo (Publish), the amount of circulating platelets significantly decreases in KI mice although not in WT Handle mice (two-way ANOVA agonist effect: P
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